Dataset Information

IL-2 and Beyond in Cancer Immunotherapy.

ABSTRACT: The development of the T- and natural killer (NK) cell growth factor IL-2 has been a sentinel force ushering in the era of immunotherapy in cancer. With the advent of clinical grade recombinant IL-2 in the mid-1980s, oncologists could for the first time directly manipulate lymphocyte populations with systemic therapy. By itself, recombinant IL-2 can induce clinical responses in up to 15% of patients with metastatic cancer or renal cell carcinoma. When administered with adoptively transferred tumor-reactive lymphocytes, IL-2 promotes T cell engraftment and response rates of up to 50% in metastatic melanoma patients. Importantly, these IL-2-driven responses can yield complete and durable responses in a subset of patients. However, the use of IL-2 is limited by toxicity and concern of the expansion of T regulatory cells. To overcome these limitations and improve response rates, other T cell growth factors, including IL-15 and modified forms of IL-2, are in clinical development. Administering T cell growth factors in combination with other agents, such as immune checkpoint pathway inhibitors, may also improve efficacy. In this study, we review the development of T- and NK cell growth factors and highlight current combinatorial approaches based on these reagents.

SUBMITTER: Wrangle JM

PROVIDER: S-EPMC5815463 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Publications

IL-2 and Beyond in Cancer Immunotherapy.

Wrangle John M JM Patterson Alicia A Johnson C Bryce CB Neitzke Daniel J DJ Mehrotra Shikhar S Denlinger Chadrick E CE Paulos Chrystal M CM Li Zihai Z Cole David J DJ Rubinstein Mark P MP

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20180201 2

The development of the T- and natural killer (NK) cell growth factor IL-2 has been a sentinel force ushering in the era of immunotherapy in cancer. With the advent of clinical grade recombinant IL-2 in the mid-1980s, oncologists could for the first time directly manipulate lymphocyte populations with systemic therapy. By itself, recombinant IL-2 can induce clinical responses in up to 15% of patients with metastatic cancer or renal cell carcinoma. When administered with adoptively transferred tum ...[more]

PMID: 29443657

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Dataset Information

IL-2 and Beyond in Cancer Immunotherapy.

Publications

IL-2 and Beyond in Cancer Immunotherapy.

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