Ontology highlight
ABSTRACT:
SUBMITTER: Bunjun R
PROVIDER: S-EPMC5815627 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Bunjun Rubina R Riou Catherine C Soares Andreia P AP Thawer Narjis N Müller Tracey L TL Kiravu Agano A Ginbot Zekarias Z Oni Tolu T Goliath Rene R Kalsdorf Barbara B von Groote-Bidlingmaier Florian F Hanekom Willem W Walzl Gerhard G Wilkinson Robert J RJ Burgers Wendy A WA
The Journal of infectious diseases 20171201 12
Human immunodeficiency virus type 1 (HIV) infection substantially increases the risk of developing tuberculosis. There is extensive depletion of Mycobacterium tuberculosis-specific CD4+ T cells in blood during early HIV infection, but little is known about responses in the lungs at this stage. Given that mucosal organs are a principal target for HIV-mediated CD4+ T-cell destruction, we investigated M. tuberculosis-specific responses in bronchoalveolar lavage (BAL) from persons with latent M. tub ...[more]