Unknown

Dataset Information

0

Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!


ABSTRACT: We have identified a phenomenon occurring in the usage of proposed "specific" Mitogen-activated protein kinase (MAPK) inhibitors. We found that especially inhibitors of p38 potentiate the activation of other MAPKs in various cell types. This finding will have tremendous impact on the interpretation of all former studies using MAPK inhibitors.

SUBMITTER: Meurer SK 

PROVIDER: S-EPMC5816342 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

altmetric image

Publications

Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!

Meurer Steffen K SK   Weiskirchen Ralf R  

Frontiers in pharmacology 20180212


We have identified a phenomenon occurring in the usage of proposed "specific" Mitogen-activated protein kinase (MAPK) inhibitors. We found that especially inhibitors of p38 potentiate the activation of other MAPKs in various cell types. This finding will have tremendous impact on the interpretation of all former studies using MAPK inhibitors. ...[more]

Similar Datasets

| S-EPMC4850115 | biostudies-literature
| S-EPMC7770057 | biostudies-literature
| S-EPMC6348722 | biostudies-literature
| S-EPMC4154568 | biostudies-literature
| S-EPMC5625047 | biostudies-literature
| S-EPMC2857444 | biostudies-literature
| S-EPMC4300142 | biostudies-literature
| S-EPMC124141 | biostudies-literature
| S-EPMC4019099 | biostudies-literature