Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota.
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ABSTRACT:
SUBMITTER: Mullaney JA
PROVIDER: S-EPMC5816355 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
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Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota.
Mullaney Jane A JA Stephens Juliette E JE Costello Mary-Ellen ME Fong Cai C Geeling Brooke E BE Gavin Patrick G PG Wright Casey M CM Spector Timothy D TD Brown Matthew A MA Hamilton-Williams Emma E EE
Microbiome 20180217 1
<h4>Background</h4>Dysbiosis of the gut microbiota has been implicated in the pathogenesis of many autoimmune conditions including type 1 diabetes (T1D). It is unknown whether changes in the gut microbiota observed in T1D are due to environmental drivers, genetic risk factors, or both. Here, we have performed an analysis of associations between the gut microbiota and T1D genetic risk using the non-obese diabetic (NOD) mouse model of T1D and the TwinsUK cohort.<h4>Results</h4>Through the analysis ...[more]
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