Ontology highlight
ABSTRACT:
SUBMITTER: Singh A
PROVIDER: S-EPMC5816602 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20180216 1
We report the first peptide based hDHFR inhibitors designed on the basis of structural analysis of dihydrofolate reductase (DHFR). A set of peptides were rationally designed and synthesized using solid phase peptide synthesis and characterized using nuclear magnetic resonance and enzyme immunoassays. The best candidate among them, a tetrapeptide, was chosen based on molecular mechanics calculations and evaluated in human lung adenocarcinoma cell line A549. It showed a significant reduction of ce ...[more]