Ontology highlight
ABSTRACT:
SUBMITTER: Yamagami T
PROVIDER: S-EPMC5816694 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Yamagami Takashi T Pleasure David E DE Lam Kit S KS Zhou Chengji J CJ
Biochemical and biophysical research communications 20180203 4
After traumatic spinal cord injury (SCI), a scar may form with a fibrotic core (fibrotic scar) and surrounding reactive astrocytes (glial scar) at the lesion site. The scar tissue is considered a major obstacle preventing regeneration both as a physical barrier and as a source for secretion of inhibitors of axonal regeneration. Understanding the mechanism of scar formation and how to control it may lead to effective SCI therapies. Using a compression-SCI model on adult transgenic mice, we demons ...[more]