Ontology highlight
ABSTRACT:
SUBMITTER: Meyer C
PROVIDER: S-EPMC5816707 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Meyer Cindy C Garzia Aitor A Mazzola Michael M Gerstberger Stefanie S Molina Henrik H Tuschl Thomas T
Molecular cell 20180201 4
TIA1 and TIAL1 encode a family of U-rich element mRNA-binding proteins ubiquitously expressed and conserved in metazoans. Using PAR-CLIP, we determined that both proteins bind target sites with identical specificity in 3' UTRs and introns proximal to 5' as well as 3' splice sites. Double knockout (DKO) of TIA1 and TIAL1 increased target mRNA abundance proportional to the number of binding sites and also caused accumulation of aberrantly spliced mRNAs, most of which are subject to nonsense-mediat ...[more]