Browse
Submit Data
Databases
API
Help

Dataset Information

8 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gold Nanoparticles as Absolute Nanothermometers.

ABSTRACT: Nanothermometry is a challenging field that can open the door to intriguing questions ranging from biology and medicine to material sciences. Gold nanorods are excellent candidates to act as nanoprobes because they are reasonably bright emitters upon excitation with a monochromatic source. Gold nanoparticles are commonly used in photothermal therapy as efficient transducers of electromagnetic radiation into heat. In this work we use the spectrum of the anti-Stokes emission from gold nanorods irradiated in resonance to measure the absolute temperature of the nanoparticles and their surrounding medium without the need for a previous calibration. We show a 4 K accuracy in the determination of the temperature of the medium with spectral measurements of 180 s integration time. This procedure can be easily implemented in any microscope capable of acquiring emission spectra, and it is not limited to any specific shape of nanoparticles.

SUBMITTER: Carattino A

PROVIDER: S-EPMC5817619 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Gold Nanoparticles as Absolute Nanothermometers.

Carattino Aquiles A Caldarola Martín M Orrit Michel M

Nano letters 20180109 2

Nanothermometry is a challenging field that can open the door to intriguing questions ranging from biology and medicine to material sciences. Gold nanorods are excellent candidates to act as nanoprobes because they are reasonably bright emitters upon excitation with a monochromatic source. Gold nanoparticles are commonly used in photothermal therapy as efficient transducers of electromagnetic radiation into heat. In this work we use the spectrum of the anti-Stokes emission from gold nanorods irr ...[more]

PMID: 29272135

Similar Datasets

in vivo neurogenesis based electromagnetized gold nanoparticles

Project description:Electromagnetized gold nanopartilces can facilitate hippocampal neurogenesis.

2021-02-19 | GSE167006 | GEO

Toxicogenomic responses of C. elegans to gold nanoparticles

Project description:We used Au nanoparticles (Au-NPs) as a model for studying particle specific effects of manufactured nanomaterials (MNMs) by examining the toxicogenomic responses in a model soil organism, free living nematode Caenorhabditis elegans. Global genome expression for nematodes exposed to 4-nm citrate-coated Au-NPs at the LC10 (5.9 mg L-1) revealed significant differential expression of 797 genes. The levels of expression for five genes (apl-1, dyn-1, act-5, abu-11, and hsp-4) were confirmed independently with qRT-PCR. Seven common biological pathways associated with 38 of these genes were identified. Activation of 26 pqn/abu genes from noncanonical Unfolded Protein Response (UPR) pathway and up-regulation of molecular chaperones (hsp-16.1, hsp-70, hsp-3 and hsp-4) were observed and are likely indicative of endoplasmic reticulum stress. Inhibition of abu-11 with RNAi showed increase in mortality in Au-NP exposed nematodes suggesting possible involvement of abu-11 (a gene associated with specific to C. elegans UPR) in a protective mechanism against Au-NPs. Exposure to Au-NPs also caused activation of genes involved in apoptosis and necrosis and resulted ultimately in 10% mortality. These results demonstrate that Au-NPs are bioavailable and cause adverse effects to a model ecoreceptor which activate both general and specific biological pathways.

2012-04-16 | GSE32521 | GEO

Toxicogenomic responses of C. elegans to gold nanoparticles

2012-04-15 | E-GEOD-32521 | biostudies-arrayexpress

SM5-1-conjugated gold nanoparticles for antibody therapy in hepatocellular carcinoma

Project description:As a humanized mouse antibody, SM5-1 can target a membrane protein of about 230kDa over-expressed in hepatocellular carcinoma (HCC), melanoma and breast cancer and it has been found to inhibit the progress of tumor cells. In this study, SM5-1 conjugated gold nanoparticles were prepared to study the antitumor efficacy in the treatment of HCC-LM3-fLuc tumor. The results showed that AU-SM5-1 could inhibit HCC-LM3 hepatocellular carcinoma cell proliferation up to 71.26% at the concentration of 0.5mg/ml contrast with SM5-1 and gold nanoparticles. In order to address the mechanism of the antiproliferative effects of AU-SM5-1, we examined the gene expression in HCC-LM3-fLuc tumor cells based on gene-chip screening.

2014-07-11 | GSE59284 | GEO

Surface Functionalities of Gold Nanoparticles (AuNPs) Impacts Embryonic Gene Expression Responses

2012-01-31 | GSE30275 | GEO

Polymer-coated gold nanoparticles target Age-Associated B cells in vivo

Project description:Engineered gold nanoparticles (GNPs) have become a useful tool in various therapeutic and diagnostic applications. Uncertainty remains regarding possible impacts of GNPs to the immune system. In this regard, we investigated the interactions of polymer-coated GNPs with B cells and their functions in mice as they constitute a crucial part of the immune system and represent a potential target for systemically administered GNPs. Surprisingly, we observed that polymer-coated GNPs mainly interact with the recently identified subpopulation of B lymphocytes named Age-associated B cells (ABCs). Importantly, we also showed that GNPs did not affect the percentages of other B cell populations in different organs. Furthermore, GNPs did not activate B cell innate-like immune responses in any of the tested conditions, nor did they impair adaptive B cell responses in immunized mice. Together, these data provide an important contribution to otherwise limited knowledge about GNP interference with B cell immune function, and demonstrate that GNPs represent a safe tool to target ABCs in vivo for various potential applications.

2022-09-01 | GSE197944 | GEO

Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag<sub>2</sub>S Nanothermometers and In Silico Simulations.

Project description:Luminescent nano-thermometry is a fast-developing technique with great potential for in vivo sensing, diagnosis, and therapy. Unfortunately, it presents serious limitations. The luminescence generated by nanothermometers, from which thermal readout is obtained, is strongly distorted by the attenuation induced by tissues. Such distortions lead to low signal levels and entangle absolute and reliable thermal monitoring of internal organs. Overcoming both limitations requires the use of high-brightness luminescent nanothermometers and adopting more complex approaches for temperature estimation. In this work, it is demonstrated how superbright Ag2S nanothermometers can provide in vivo, reliable, and absolute thermal reading of the liver during laser-induced hyperthermia. For that, a new procedure is designed in which thermal readout is obtained from the combination of in vivo transient thermometry measurements and in silico simulations. The synergy between in vivo and in silico measurements has made it possible to assess relevant numbers such as the efficiency of hyperthermia processes, the total heat energy deposited in the liver, and the relative contribution of Ag2S nanoparticles to liver heating. This work provides a new way for absolute thermal sensing of internal organs with potential application not only to hyperthermia processes but also to advanced diagnosis and therapy.

| S-EPMC8097345 | biostudies-literature

in vivo neurogenesis based electromagnetized gold nanoparticles

Project description:in vivo neurogenesis based electromagnetized gold nanoparticles

| PRJNA702647 | ENA

Surface Functionalities of Gold Nanoparticles (AuNPs) Impacts Embryonic Gene Expression Responses

Project description:Investigation of whole genome expression pattern of 24 and 48 hours post fertilization Danio Rerio embryos exposed to 1.5nm MES- and TMAT- AuNPs. TMAT is a positively charged (cationic) ligand, and MES is a negatively charged (anionic) ligand. Embryos were exposed to 10ug/mL of 1.5nm TMAT-AuNPs, 50ug/mL of 1.5nm MES-AuNPs or control from 6hpf to 24 or 48 hpf. Three replicates were collected for each time point. 40 embryos were pooled to comprise a replicate.

2012-01-31 | E-GEOD-30275 | biostudies-arrayexpress

SM5-1-conjugated gold nanoparticles for antibody therapy in hepatocellular carcinoma

2014-07-11 | E-GEOD-59284 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data