Ontology highlight
ABSTRACT:
SUBMITTER: Roman M
PROVIDER: S-EPMC5817724 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Román Marta M Baraibar Iosune I López Inés I Nadal Ernest E Rolfo Christian C Vicent Silvestre S Gil-Bazo Ignacio I
Molecular cancer 20180219 1
Lung neoplasms are the leading cause of death by cancer worldwide. Non-small cell lung cancer (NSCLC) constitutes more than 80% of all lung malignancies and the majority of patients present advanced disease at onset. However, in the last decade, multiple oncogenic driver alterations have been discovered and each of them represents a potential therapeutic target. Although KRAS mutations are the most frequently oncogene aberrations in lung adenocarcinoma patients, effective therapies targeting KRA ...[more]