Ontology highlight
ABSTRACT:
SUBMITTER: Mathew B
PROVIDER: S-EPMC5817852 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Mathew Bini B Hobrath Judith V JV Connelly Michele C MC Guy R Kiplin RK Reynolds Robert C RC
The open medicinal chemistry journal 20180131
<h4>Background</h4>Sulindac belongs to the chemically diverse family of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) that effectively prevent adenomatous colorectal polyps and colon cancer, especially in patients with familial adenomatous polyposis. Sulindac sulfide amide (SSA), an amide analog of sulindac sulfide, shows insignificant COX-related activity and toxicity while enhancing anticancer activity <i>in vitro</i> and demonstrating <i>in vivo</i> xenograft activity.<h4>Objective</h4>Devel ...[more]