ITRAQ-based quantitative proteomic analysis reveals important metabolic pathways for arsenic-induced liver fibrosis in rats.

ABSTRACT: Long-term consumption of sodium arsenite contaminated water can cause endemic arsenic disease. The proteome profile changes of liver fibrosis after exposure to arsenite containing water remain unclear. In this study, Sprague-Dawley (SD) male rats were treated with sodium arsenite (iAs3+), using a daily dose of 1.36?mg/kg body weight (medium dose group, M), 2.73?mg/kg body weight (high dose group, H) or deionized water (control group, C). Isobaric tags for relative and absolute quantitation (iTRAQ) were used to identify the different abundant proteins (DAPs) after arsenic-induced liver fibrosis. A total of 2987 high-quality proteins were detected (95% confident peptides???2), 608 of which were differentially expressed (fold change?>?2 and p?

SUBMITTER: Wu S 

PROVIDER: S-EPMC5818499 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature