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Thermodynamic secrets of multidrug resistance: A new take on transport mechanisms of secondary active antiporters.


ABSTRACT: Multidrug resistance (MDR) presents a growing challenge to global public health. Drug extrusion transporters play a critical part in MDR; thus, their mechanisms of substrate recognition are being studied in great detail. In this work, we review common structural features of key transporters involved in MDR. Based on our membrane potential-driving hypothesis, we propose a general energy-coupling mechanism for secondary-active antiporters. This putative mechanism provides a common framework for understanding poly-specificity of most-if not all-MDR transporters.

SUBMITTER: Zhang XC 

PROVIDER: S-EPMC5818768 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Thermodynamic secrets of multidrug resistance: A new take on transport mechanisms of secondary active antiporters.

Zhang Xuejun C XC   Liu Min M   Lu Guangyuan G   Heng Jie J  

Protein science : a publication of the Protein Society 20171215 3


Multidrug resistance (MDR) presents a growing challenge to global public health. Drug extrusion transporters play a critical part in MDR; thus, their mechanisms of substrate recognition are being studied in great detail. In this work, we review common structural features of key transporters involved in MDR. Based on our membrane potential-driving hypothesis, we propose a general energy-coupling mechanism for secondary-active antiporters. This putative mechanism provides a common framework for un  ...[more]

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