Thermodynamic secrets of multidrug resistance: A new take on transport mechanisms of secondary active antiporters.
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ABSTRACT:
SUBMITTER: Zhang XC
PROVIDER: S-EPMC5818768 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Thermodynamic secrets of multidrug resistance: A new take on transport mechanisms of secondary active antiporters.
Zhang Xuejun C XC Liu Min M Lu Guangyuan G Heng Jie J
Protein science : a publication of the Protein Society 20171215 3
Multidrug resistance (MDR) presents a growing challenge to global public health. Drug extrusion transporters play a critical part in MDR; thus, their mechanisms of substrate recognition are being studied in great detail. In this work, we review common structural features of key transporters involved in MDR. Based on our membrane potential-driving hypothesis, we propose a general energy-coupling mechanism for secondary-active antiporters. This putative mechanism provides a common framework for un ...[more]
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