Ontology highlight
ABSTRACT:
SUBMITTER: Bruner JK
PROVIDER: S-EPMC5819342 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Bruner J Kyle JK Ma Hayley S HS Li Li L Qin Alice Can Ran ACR Rudek Michelle A MA Jones Richard J RJ Levis Mark J MJ Pratz Keith W KW Pratilas Christine A CA Small Donald D
Cancer research 20170918 20
FMS-like tyrosine kinase-3 (FLT3) tyrosine kinase inhibitors (TKI) have been tested extensively to limited benefit in acute myeloid leukemia (AML). We hypothesized that FLT3/internal tandem duplication (ITD) leukemia cells exhibit mechanisms of intrinsic signaling adaptation to TKI treatment that are associated with an incomplete response. Here, we identified reactivation of ERK signaling within hours following treatment of FLT3/ITD AML cells with selective inhibitors of FLT3. When these cells w ...[more]