Ontology highlight
ABSTRACT:
SUBMITTER: Raanan H
PROVIDER: S-EPMC5819401 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Raanan Hagai H Pike Douglas H DH Moore Eli K EK Falkowski Paul G PG Nanda Vikas V
Proceedings of the National Academy of Sciences of the United States of America 20180122 6
Oxidoreductases catalyze electron transfer reactions that ultimately provide the energy for life. A limited set of ancestral protein-metal modules are presumably the building blocks that evolved into this diverse protein family. However, the identity of these modules and their path to modern oxidoreductases is unknown. Using a comparative structural analysis approach, we identify a set of fundamental electron transfer modules that have evolved to form the extant oxidoreductases. Using transition ...[more]