Ontology highlight
ABSTRACT:
SUBMITTER: Farley JE
PROVIDER: S-EPMC5819420 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Farley Jonathan E JE Burdett Thomas C TC Barria Romina R Neukomm Lukas J LJ Kenna Kevin P KP Landers John E JE Freeman Marc R MR
Proceedings of the National Academy of Sciences of the United States of America 20180102 6
Genetic studies of Wallerian degeneration have led to the identification of signaling molecules (e.g., dSarm/Sarm1, Axundead, and Highwire) that function locally in axons to drive degeneration. Here we identify a role for the <i>Drosophila</i> C<sub>2</sub>H<sub>2</sub> zinc finger transcription factor Pebbled [Peb, Ras-responsive element binding protein 1 (RREB1) in mammals] in axon death. Loss of Peb in <i>Drosophila</i> glutamatergic sensory neurons results in either complete preservation of ...[more]