Ontology highlight
ABSTRACT:
SUBMITTER: Yoon D
PROVIDER: S-EPMC5819827 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Yoon Daseul D Bae Kieun K Lee Min-Kyeong MK Kim Jin Hee JH Yoon Kyong-Ah KA
PloS one 20180220 2
Galanin is a 30 amino-acid active neuropeptide that acts via three G-protein coupled galanin receptors, GALR1, GALR2 and GALR3. Recently, GALR1 was also suggested as a tumor suppressor gene that was frequently silenced in head and neck squamous cell carcinoma; moreover, galanin and GALR1 were reported to inhibit human oral cancer cell proliferation. However, the exact role of galanin in gastric cancer is unclear. Here, we describe the epigenetic silencing of galanin in human gastric cancer. Five ...[more]