Ontology highlight
ABSTRACT:
SUBMITTER: Sieber J
PROVIDER: S-EPMC5819995 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Sieber Jonas J Wieder Nicolas N Clark Abbe A Reitberger Manuel M Matan Sofia S Schoenfelder Jeannine J Zhang Jianming J Mandinova Anna A Bittker Joshua Adam JA Gutierrez Juan J Aygün Ozan O Udeshi Namrata N Carr Steven S Mundel Peter P Jehle Andreas Werner AW Greka Anna A
Cell chemical biology 20171214 2
Progressive kidney diseases affect approximately 500 million people worldwide. Podocytes are terminally differentiated cells of the kidney filter, the loss of which leads to disease progression and kidney failure. To date, there are no therapies to promote podocyte survival. Drug repurposing may therefore help accelerate the development of cures in an area of tremendous unmet need. In a newly developed high-throughput screening assay of podocyte viability, we identified the BRAF<sup>V600E</sup> ...[more]