Ontology highlight
ABSTRACT:
SUBMITTER: Yoo IY
PROVIDER: S-EPMC5820071 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Yoo In Young IY Lee Kyunghoon K Ji Ok Ja OJ Woo Hye In HI Lee Soo Youn SY
Annals of laboratory medicine 20180501 3
Measurement of thiopurine metabolites is helpful to monitor adverse effects and assess compliance in patients on thiopurine treatment. The purpose of this study was to develop and validate an analytical method for measurement of thiopurine metabolites, thioguanine nucleotides (6-TGN) and 6-methylmercaptopurine nucleotide (6-MMPN), in RBCs. We developed and validated a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of 6-TGN and 6-MMPN and evaluated the sta ...[more]