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Hospital readmissions following HLA-incompatible live donor kidney transplantation: A multi-center study.


ABSTRACT: Thirty percent of kidney transplant recipients are readmitted in the first month posttransplantation. Those with donor-specific antibody requiring desensitization and incompatible live donor kidney transplantation (ILDKT) constitute a unique subpopulation that might be at higher readmission risk. Drawing on a 22-center cohort, 379 ILDKTs with Medicare primary insurance were matched to compatible transplant-matched controls and to waitlist-only matched controls on panel reactive antibody, age, blood group, renal replacement time, prior kidney transplantation, race, gender, diabetes, and transplant date/waitlisting date. Readmission risk was determined using multilevel, mixed-effects Poisson regression. In the first month, ILDKTs had a 1.28-fold higher readmission risk than compatible controls (95% confidence interval [CI] 1.13-1.46; P < .001). Risk peaked at 6-12 months (relative risk [RR] 1.67, 95% CI 1.49-1.87; P < .001), attenuating by 24-36 months (RR 1.24, 95% CI 1.10-1.40; P < .001). ILDKTs had a 5.86-fold higher readmission risk (95% CI 4.96-6.92; P < .001) in the first month compared to waitlist-only controls. At 12-24 (RR 0.85, 95% CI 0.77-0.95; P = .002) and 24-36 months (RR 0.74, 95% CI 0.66-0.84; P < .001), ILDKTs had a lower risk than waitlist-only controls. These findings of ILDKTs having a higher readmission risk than compatible controls, but a lower readmission risk after the first year than waitlist-only controls should be considered in regulatory/payment schemas and planning clinical care.

SUBMITTER: Orandi BJ 

PROVIDER: S-EPMC5820188 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Hospital readmissions following HLA-incompatible live donor kidney transplantation: A multi-center study.

Orandi Babak J BJ   Luo Xun X   King Elizabeth A EA   Garonzik-Wang Jacqueline M JM   Bae Sunjae S   Montgomery Robert A RA   Stegall Mark D MD   Jordan Stanley C SC   Oberholzer Jose J   Dunn Ty B TB   Ratner Lloyd E LE   Kapur Sandip S   Pelletier Ronald P RP   Roberts John P JP   Melcher Marc L ML   Singh Pooja P   Sudan Debra L DL   Posner Marc P MP   El-Amm Jose M JM   Shapiro Ron R   Cooper Matthew M   Lipkowitz George S GS   Rees Michael A MA   Marsh Christopher L CL   Sankari Bashir R BR   Gerber David A DA   Nelson Paul W PW   Wellen Jason J   Bozorgzadeh Adel A   Osama Gaber A A   Segev Dorry L DL  

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20170923 3


Thirty percent of kidney transplant recipients are readmitted in the first month posttransplantation. Those with donor-specific antibody requiring desensitization and incompatible live donor kidney transplantation (ILDKT) constitute a unique subpopulation that might be at higher readmission risk. Drawing on a 22-center cohort, 379 ILDKTs with Medicare primary insurance were matched to compatible transplant-matched controls and to waitlist-only matched controls on panel reactive antibody, age, bl  ...[more]

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