Changed frontal pole gene expression suggest altered interplay between neurotransmitter, developmental, and inflammatory pathways in schizophrenia.
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ABSTRACT:
SUBMITTER: Scarr E
PROVIDER: S-EPMC5820249 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
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Changed frontal pole gene expression suggest altered interplay between neurotransmitter, developmental, and inflammatory pathways in schizophrenia.
Scarr Elizabeth E Udawela Madhara M Dean Brian B
NPJ schizophrenia 20180220 1
Schizophrenia (Sz) probably occurs after genetically susceptible individuals encounter a deleterious environmental factor that triggers epigenetic mechanisms to change CNS gene expression. To determine if omnibus changes in CNS gene expression are present in Sz, we compared mRNA levels in the frontal pole (Brodmann's area (BA) 10), the dorsolateral prefrontal cortex (BA 9) and cingulate cortex (BA 33) from 15 subjects with Sz and 15 controls using the Affymetrix™ Human Exon 1.0 ST Array. Differe ...[more]
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