Ontology highlight
ABSTRACT:
SUBMITTER: Pellefigues C
PROVIDER: S-EPMC5820278 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Pellefigues Christophe C Dema Barbara B Lamri Yasmine Y Saidoune Fanny F Chavarot Nathalie N Lohéac Charlotte C Pacreau Emeline E Dussiot Michael M Bidault Caroline C Marquet Florian F Jablonski Mathieu M Chemouny Jonathan M JM Jouan Fanny F Dossier Antoine A Chauveheid Marie-Paule MP Gobert Delphine D Papo Thomas T Karasuyama Hajime H Sacré Karim K Daugas Eric E Charles Nicolas N
Nature communications 20180220 1
In systemic lupus erythematosus (SLE), autoantibody production can lead to kidney damage and failure, known as lupus nephritis. Basophils amplify the synthesis of autoantibodies by accumulating in secondary lymphoid organs. Here, we show a role for prostaglandin D<sub>2</sub> (PGD<sub>2</sub>) in the pathophysiology of SLE. Patients with SLE have increased expression of PGD<sub>2</sub> receptors (PTGDR) on blood basophils and increased concentration of PGD<sub>2</sub> metabolites in plasma. Thro ...[more]