Gene Expression Meta-Analysis of Seven Candidate Gene Sets for Diabetes Traits Following a GWAS Pathway Study.
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ABSTRACT:
SUBMITTER: Mei H
PROVIDER: S-EPMC5820295 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Gene Expression Meta-Analysis of Seven Candidate Gene Sets for Diabetes Traits Following a GWAS Pathway Study.
Mei Hao H Li Lianna L Griswold Michael M Mosley Thomas T
Frontiers in genetics 20180216
Seven gene sets were significantly enriched for SNP associations with diabetes, and considered as potential diabetes pathways in a previous meta-analysis of diabetes GWAS. This study aims to examine if these gene sets also have expression associations with diabetes. The analysis was conducted using pooled data from 23 diabetes gene expression studies. Gene associations were examined using linear modeling with an empirical Bayes approach, and pathway associations were investigated by testing enri ...[more]
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