Ontology highlight
ABSTRACT:
SUBMITTER: Collar AL
PROVIDER: S-EPMC5821174 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Collar Amanda L AL Swamydas Muthulekha M O'Hayre Morgan M Sajib Md Sanaullah MS Hoffman Kevin W KW Singh Satya P SP Mourad Ahmad A Johnson Melissa D MD Ferre Elise Mn EM Farber Joshua M JM Lim Jean K JK Mikelis Constantinos M CM Gutkind J Silvio JS Lionakis Michail S MS
JCI insight 20180208 3
Several reports have demonstrated that mouse Cx3cr1 signaling promotes monocyte/macrophage survival. In agreement, we previously found that, in a mouse model of systemic candidiasis, genetic deficiency of Cx3cr1 resulted in increased mortality and impaired tissue fungal clearance associated with decreased macrophage survival. We translated this finding by showing that the dysfunctional CX3CR1 variant CX3CR1-M280 was associated with increased risk and worse outcome of human systemic candidiasis. ...[more]