Ontology highlight
ABSTRACT:
SUBMITTER: Rajagopal R
PROVIDER: S-EPMC5821215 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Rajagopal Rithwick R Zhang Sheng S Wei Xiaochao X Doggett Teresa T Adak Sangeeta S Enright Jennifer J Shah Vaishali V Ling Guoyu G Chen Shiming S Yoshino Jun J Hsu Fong-Fu FF Semenkovich Clay F CF
JCI insight 20180111 1
Membrane lipid composition is central to the highly specialized functions of neurological tissues. In the retina, abnormal lipid metabolism causes severe forms of blindness, often through poorly understood neuronal cell death. Here, we demonstrate that deleting the de novo lipogenic enzyme fatty acid synthase (FAS) from the neural retina, but not the vascular retina, results in progressive neurodegeneration and blindness with a temporal pattern resembling rodent models of retinitis pigmentosa. B ...[more]