Ontology highlight
ABSTRACT:
SUBMITTER: Raaben M
PROVIDER: S-EPMC5821226 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Raaben Matthijs M Jae Lucas T LT Herbert Andrew S AS Kuehne Ana I AI Stubbs Sarah H SH Chou Yi-Ying YY Blomen Vincent A VA Kirchhausen Tomas T Dye John M JM Brummelkamp Thijn R TR Whelan Sean P SP
Cell host & microbe 20171101 5
Arenaviruses cause fatal hemorrhagic disease in humans. Old World arenavirus glycoproteins (GPs) mainly engage α-dystroglycan as a cell-surface receptor, while New World arenaviruses hijack transferrin receptor. However, the Lujo virus (LUJV) GP does not cluster with New or Old World arenaviruses. Using a recombinant vesicular stomatitis virus containing LUJV GP as its sole attachment and fusion protein (VSV-LUJV), we demonstrate that infection is independent of known arenavirus receptor genes. ...[more]