Ontology highlight
ABSTRACT:
SUBMITTER: Policicchio BB
PROVIDER: S-EPMC5821307 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Policicchio Benjamin Bruno BB Sette Paola P Xu Cuiling C Haret-Richter George G Dunsmore Tammy T Pandrea Ivona I Ribeiro Ruy M RM Apetrei Cristian C
PloS one 20180221 2
Two SIVmac251-infected rhesus macaques received tenofovir/emtricitabine with raltegravir intensification. Viral rebound occurred during treatment and sequencing of reverse transcriptase and integrase genes identified multiple resistance mutations. Similar to HIV infection, antiretroviral-resistance mutations may occur in SIV-infected nonhuman primates receiving nonsuppressive ART. As ART administration to nonhuman primates is currently dramatically expanding, fueled by both cure research and the ...[more]