Ontology highlight
ABSTRACT:
SUBMITTER: Kolog Gulko M
PROVIDER: S-EPMC5821377 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Kolog Gulko Miriam M Heinrich Gabriele G Gross Carina C Popova Blagovesta B Valerius Oliver O Neumann Piotr P Ficner Ralf R Braus Gerhard H GH
PLoS genetics 20180205 2
The transition from vegetative growth to multicellular development represents an evolutionary hallmark linked to an oxidative stress signal and controlled protein degradation. We identified the Sem1 proteasome subunit, which connects stress response and cellular differentiation. The sem1 gene encodes the fungal counterpart of the human Sem1 proteasome lid subunit and is essential for fungal cell differentiation and development. A sem1 deletion strain of the filamentous fungus Aspergillus nidulan ...[more]