Ontology highlight
ABSTRACT:
SUBMITTER: Kichatova VS
PROVIDER: S-EPMC5821972 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Kichatova V S VS Kyuregyan K K KK Soboleva N V NV Karlsen A A AA Isaeva O V OV Isaguliants M G MG Mikhailov M I MI
Journal of immunology research 20180207
Amino acid substitutions R70Q/H and L91M in HCV subtype 1b core protein can affect the response to interferon and are associated with the development of hepatocellular carcinoma. We found that the rate of R70Q/H in HCV 1b from Russia was 31.2%, similar to that in HCV strains from Asia (34.0%), higher than that in the European (18.0%, <i>p</i> = 0.0010), but lower than that in the US HCV 1b strains (62.8%, <i>p</i> < 0.0001). Substitution L91M was found in 80.4% of the Russian HCV 1b isolates, hi ...[more]