Ontology highlight
ABSTRACT:
SUBMITTER: Vlaar CP
PROVIDER: S-EPMC5822041 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Vlaar Cornelis P CP Castillo-Pichardo Linette L Medina Julia I JI Marrero-Serra Cathyria M CM Vélez Ericka E Ramos Zulma Z Hernández Eliud E
Bioorganic & medicinal chemistry 20180111 4
Based on the efficacy of EHop-016 as an inhibitor of migration and Rac1 activation, a new series of carbazole derivatives has been synthesized. Cytotoxic and anti-migratory effects of these compounds were evaluated in MCF-7 and MDA-MB-231 breast cancer cell lines. Preliminary investigations of their anticancer activity demonstrated that several compounds have moderate antiproliferative effects on cancer cell lines with GI<sub>50</sub> values in the range of 13-50 µM. Furthermore, compounds 3b an ...[more]