Ontology highlight
ABSTRACT:
SUBMITTER: Gaiani A
PROVIDER: S-EPMC5822207 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Gaiani Alessandra A Martinelli Ilaria I Bello Luca L Querin Giorgia G Puthenparampil Marco M Ruggero Susanna S Toffanin Elisabetta E Cagnin Annachiara A Briani Chiara C Pegoraro Elena E Sorarù Gianni G
JAMA neurology 20170501 5
<h4>Importance</h4>A clearer definition of the role of neurofilament light chain (NFL) as a biomarker in amyotrophic lateral sclerosis (ALS) is needed.<h4>Objectives</h4>To assess the ability of NFL to serve as a diagnostic biomarker in ALS and the prognostic value of cerebrospinal fluid NFL in patients with ALS.<h4>Design, setting, and participants</h4>In this single-center, retrospective, longitudinal study, disease progression was assessed by the ALS Functional Rating Score-Revised and the AL ...[more]