Ontology highlight
ABSTRACT:
SUBMITTER: Barajas-Olmos F
PROVIDER: S-EPMC5822594 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Barajas-Olmos Francisco F Centeno-Cruz Federico F Zerrweck Carlos C Imaz-Rosshandler Iván I Martínez-Hernández Angélica A Cordova Emilio J EJ Rangel-Escareño Claudia C Gálvez Faustino F Castillo Armando A Maydón Hernán H Campos Francisco F Maldonado-Pintado Diana Gabriela DG Orozco Lorena L
BMC medical genetics 20180221 1
<h4>Background</h4>Obesity is a well-recognized risk factor for insulin resistance and type 2 diabetes (T2D), although the precise mechanisms underlying the relationship remain unknown. In this study we identified alterations of DNA methylation influencing T2D pathogenesis, in subcutaneous and visceral adipose tissues, liver, and blood from individuals with obesity.<h4>Methods</h4>The study included individuals with obesity, with and without T2D. From these patients, we obtained samples of liver ...[more]