Perioperative dynamics and significance of plasma-free amino acid profiles in colorectal cancer.

ABSTRACT:

Background

For early detection of cancer, we have previously developed the AminoIndex Cancer Screening (AICS) system, which quantifies 6 plasma-free amino acids (PFAAs) in blood samples. Herein, we examined the usefulness of the AICS in patients with colorectal cancer (CRC) by comparing the preoperative and postoperative PFAA profiles.

Methods

Our study cohort consisted of 62 patients who had undergone curative resection for CRC at our cancer center, with no recurrence at the time of the study. Blood samples were collected from fasted patients within 1 week before the resection and at 0.5-6.5 years post-resection. Following plasmapheresis, the PFAA levels were measured via liquid chromatography/mass spectrometry, and the AICS values were computed (the higher the value, the g

SUBMITTER: Katayama K 

PROVIDER: S-EPMC5822659 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature