In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis.
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ABSTRACT:
SUBMITTER: Storm PA
PROVIDER: S-EPMC5822715 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis.
Storm Philip A PA Townsend Craig A CA
Chemical communications (Cambridge, England) 20171201 1
Polyketide synthases (PKSs) have several known editing mechanisms to ensure that non-productive intermediates are removed from the acyl carrier protein (ACP). We demonstrate that CitA, a putative hydrolase in the citrinin biosynthetic gene cluster, removes ACP-bound acyl intermediates. We propose that it serves an editing role in trans. ...[more]
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