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Latent-Profile Analysis Reveals Behavioral and Brain Correlates of Dopamine-Cognition Associations.

ABSTRACT: Evidence suggests that associations between the neurotransmitter dopamine and cognition are nonmonotonic and open to modulation by various other factors. The functional implications of a given level of dopamine may therefore differ from person to person. By applying latent-profile analysis to a large (n = 181) sample of adults aged 64-68 years, we probabilistically identified 3 subgroups that explain the multivariate associations between dopamine D2/3R availability (probed with 11C-raclopride-PET, in cortical, striatal, and hippocampal regions) and cognitive performance (episodic memory, working memory, and perceptual speed). Generally, greater receptor availability was associated with better cognitive performance. However, we discovered a subgroup of individuals for which high availability, particularly in striatum, was associated with poor performance, especially for working memory. Relative to the rest of the sample, this subgroup also had lower education, higher body-mass index, and lower resting-state connectivity between caudate nucleus and dorsolateral prefrontal cortex. We conclude that a smaller subset of individuals induces a multivariate non-linear association between dopamine D2/3R availability and cognitive performance in this group of older adults, and discuss potential reasons for these differences that await further empirical scrutiny.

SUBMITTER: Lovden M

PROVIDER: S-EPMC5823239 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Latent-Profile Analysis Reveals Behavioral and Brain Correlates of Dopamine-Cognition Associations.

Lövdén Martin M Karalija Nina N Andersson Micael M Wåhlin Anders A Axelsson Jan J Köhncke Ylva Y Jonasson Lars S LS Rieckman Anna A Papenberg Goran G Garrett Douglas D DD Guitart-Masip Marc M Salami Alireza A Riklund Katrine K Bäckman Lars L Nyberg Lars L Lindenberger Ulman U

Cerebral cortex (New York, N.Y. : 1991) 20181101 11

Evidence suggests that associations between the neurotransmitter dopamine and cognition are nonmonotonic and open to modulation by various other factors. The functional implications of a given level of dopamine may therefore differ from person to person. By applying latent-profile analysis to a large (n = 181) sample of adults aged 64-68 years, we probabilistically identified 3 subgroups that explain the multivariate associations between dopamine D2/3R availability (probed with 11C-raclopride-PE ...[more]

PMID: 29028935

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Latent-Profile Analysis Reveals Behavioral and Brain Correlates of Dopamine-Cognition Associations.

Publications

Latent-Profile Analysis Reveals Behavioral and Brain Correlates of Dopamine-Cognition Associations.

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