Ontology highlight
ABSTRACT:
SUBMITTER: Reifenberger JG
PROVIDER: S-EPMC5823525 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Reifenberger Jeffrey G JG Cao Han H Dorfman Kevin D KD
Macromolecules 20180124 3
We report experimental data on the unfolding of human and <i>E. coli</i> genomic DNA molecules shortly after injection into a 45 nm nanochannel. The unfolding dynamics are deterministic, consistent with previous experiments and modeling in larger channels, and do not depend on the biological origin of the DNA. The measured entropic unfolding force per friction per unit contour length agrees with that predicted by combining the Odijk excluded volume with numerical calculations of the Kirkwood dif ...[more]