Ontology highlight
ABSTRACT:
SUBMITTER: Castellano BM
PROVIDER: S-EPMC5823611 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Castellano Brian M BM Thelen Ashley M AM Moldavski Ofer O Feltes McKenna M van der Welle Reini E N RE Mydock-McGrane Laurel L Jiang Xuntian X van Eijkeren Robert J RJ Davis Oliver B OB Louie Sharon M SM Perera Rushika M RM Covey Douglas F DF Nomura Daniel K DK Ory Daniel S DS Zoncu Roberto R
Science (New York, N.Y.) 20170301 6331
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that becomes activated at the lysosome in response to nutrient cues. Here, we identify cholesterol, an essential building block for cellular growth, as a nutrient input that drives mTORC1 recruitment and activation at the lysosomal surface. The lysosomal transmembrane protein, SLC38A9, is required for mTORC1 activation by cholesterol through conserved cholesterol-responsive motifs. Moreover, SLC38A ...[more]