Ontology highlight
ABSTRACT:
SUBMITTER: Drube J
PROVIDER: S-EPMC5823647 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Drube Julia J Ernst Thomas T Pfirrmann Markus M Albert Benadict Vincent BV Drube Sebastian S Reich Daniela D Kresinsky Anne A Halfter Kathrin K Sorio Claudio C Fabisch Christian C Hochhaus Andreas A Böhmer Frank-D FD
Oncotarget 20180115 10
The introduction of second-generation tyrosine kinase inhibitors (TKIs) targeting the protein-tyrosine kinase (PTK) BCR-ABL1 has improved treatment response in chronic myeloid leukemia (CML). However, in some patients response still remains suboptimal. Protein-tyrosine phosphatases (PTPs) are natural counter-actors of PTK activity and can affect TKI sensitivity, but the impact of PTPs on treatment response to second-generation TKIs is unknown. We assessed the mRNA expression level of 38 PTPs in ...[more]