Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC5823691 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Chen Jinshui J Song Yun Y Bojadzic Damir D Tamayo-Garcia Alejandro A Landin Ana Marie AM Blomberg Bonnie B BB Buchwald Peter P
Journal of medicinal chemistry 20171025 21
Costimulatory interactions are required for T cell activation and development of an effective immune response; hence, they are valuable therapeutic targets for immunomodulation. However, they, as all other protein-protein interactions, are difficult to target by small molecules. Here, we report the identification of novel small-molecule inhibitors of the CD40-CD40L interaction designed starting from the chemical space of organic dyes. For the most promising compounds such as DRI-C21045, activity ...[more]