Survival outcomes in pediatric recurrent high-grade glioma: results of a 20-year systematic review and meta-analysis.

ABSTRACT: Recurrent pediatric high-grade glioma is a leading cause of cancer-related death in children. We report results of a systematic review and meta-analysis investigating survival outcome in pediatric patients with recurrent high-grade glioma over the last 20 years. MEDLINE/PubMed, EMBASE, Web of Science and Cochrane Review databases were searched for relevant studies reporting on survival outcomes for pediatric patients with recurrent high-grade glioma treated between 1996 and 2016. Progression-free survival (PFS) and overall survival (OS) were calculated cumulatively over all studies, by therapy subgroup, and by decade of treatment. Random effects models were used to control for heterogeneity as measured by the I² statistic. A total of 17 studies across 4 treatment strategies were

SUBMITTER: Kline C 

PROVIDER: S-EPMC5823744 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature