The Drift in Molecular Testing for Influenza: Mutations Affecting Assay Performance.
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ABSTRACT:
SUBMITTER: Stellrecht KA
PROVIDER: S-EPMC5824055 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
The Drift in Molecular Testing for Influenza: Mutations Affecting Assay Performance.
Journal of clinical microbiology 20180222 3
Influenza is associated with rapid evolution due to lack of RNA polymerase proofreading, immunogenic selection, and frequent rearrangement of gene segments. Evolutionary changes affecting the performance of diagnostic testing have long been recognized. Hence, it is not surprising that such challenges apply to nucleic acid amplification tests, even though they are designed to target highly conserved regions. Initially, case reports involved single isolates of A(H1N1)pdm09. Over the past 4 years, ...[more]
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