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Translational Systems Pharmacology Studies in Pregnant Women.


ABSTRACT: Pregnancy involves rapid physiological adaptation and complex interplay between mother and fetus. New analytic technologies provide large amounts of genomic, proteomic, and metabolomics data. The integration of these data through bioinformatics, statistical, and systems pharmacology techniques can improve our understanding of the mechanisms of normal maternal physiologic changes and fetal development. New insights into the mechanisms of pregnancy-related disorders, such as preterm birth (PTB), may lead to the development of new therapeutic interventions and novel biomarkers.

SUBMITTER: Quinney SK 

PROVIDER: S-EPMC5824114 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Translational Systems Pharmacology Studies in Pregnant Women.

Quinney Sara K SK   Gullapelli Rakesh R   Haas David M DM  

CPT: pharmacometrics & systems pharmacology 20171214 2


Pregnancy involves rapid physiological adaptation and complex interplay between mother and fetus. New analytic technologies provide large amounts of genomic, proteomic, and metabolomics data. The integration of these data through bioinformatics, statistical, and systems pharmacology techniques can improve our understanding of the mechanisms of normal maternal physiologic changes and fetal development. New insights into the mechanisms of pregnancy-related disorders, such as preterm birth (PTB), m  ...[more]

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