Dihydroartemisinin up-regulates VE-cadherin expression in human renal glomerular endothelial cells.
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ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC5824371 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
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Dihydroartemisinin up-regulates VE-cadherin expression in human renal glomerular endothelial cells.
Li Liqun L Chen Xiaocui X Dong Fengyun F Liu Qiang Q Zhang Caiqing C Xu Dongmei D Allen Thaddeus D TD Liu Ju J
Journal of cellular and molecular medicine 20171129 3
The antimalarial agent dihydroartemisinin (DHA) has been shown to be anti-inflammatory. In this study, we found that DHA increased the expression of the junctional protein vascular endothelial (VE)-cadherin in human renal glomerular endothelial cells. In addition, DHA inhibited TGF-β RI-Smad2/3 signalling and its downstream effectors SNAIL and SLUG, which repress VE-cadherin gene transcription. Correspondingly, DHA decreased the binding of SNAIL and SLUG to the VE-cadherin promoter. Together, ou ...[more]
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