Ontology highlight
ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC5824635 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Wang Fuli F Zhang Hongyong H Ma Ai-Hong AH Yu Weimin W Zimmermann Maike M Yang Jun J Hwang Sung Hee SH Zhu Daniel D Lin Tzu-Yin TY Malfatti Michael M Turteltaub Kenneth W KW Henderson Paul T PT Airhart Susan S Hammock Bruce D BD Yuan Jianlin J de Vere White Ralph W RW Pan Chong-Xian CX
Molecular cancer therapeutics 20171228 2
Cisplatin-based therapy is highly toxic, but moderately effective in most cancers. Concurrent inhibition of cyclooxygenase-2 (COX-2) and soluble epoxide hydrolase (sEH) results in antitumor activity and has organ-protective effects. The goal of this study was to determine the antitumor activity of PTUPB, an orally bioavailable COX-2/sEH dual inhibitor, in combination with cisplatin and gemcitabine (GC) therapy. NSG mice bearing bladder cancer patient-derived xenografts were treated with vehicle, ...[more]