Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.
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ABSTRACT:
SUBMITTER: Li CW
PROVIDER: S-EPMC5824730 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.
Li Chia-Wei CW Lim Seung-Oe SO Chung Ezra M EM Kim Yong-Soo YS Park Andrew H AH Yao Jun J Cha Jong-Ho JH Xia Weiya W Chan Li-Chuan LC Kim Taewan T Chang Shih-Shin SS Lee Heng-Huan HH Chou Chao-Kai CK Liu Yen-Liang YL Yeh Hsin-Chih HC Perillo Evan P EP Dunn Andrew K AK Kuo Chu-Wei CW Khoo Kay-Hooi KH Hsu Jennifer L JL Wu Yun Y Hsu Jung-Mao JM Yamaguchi Hirohito H Huang Tzu-Hsuan TH Sahin Aysegul A AA Hortobagyi Gabriel N GN Yoo Stephen S SS Hung Mien-Chie MC
Cancer cell 20180201 2
Protein glycosylation provides proteomic diversity in regulating protein localization, stability, and activity; it remains largely unknown whether the sugar moiety contributes to immunosuppression. In the study of immune receptor glycosylation, we showed that EGF induces programmed death ligand 1 (PD-L1) and receptor programmed cell death protein 1 (PD-1) interaction, requiring β-1,3-N-acetylglucosaminyl transferase (B3GNT3) expression in triple-negative breast cancer. Downregulation of B3GNT3 e ...[more]
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