Ontology highlight
ABSTRACT:
SUBMITTER: Martinez P
PROVIDER: S-EPMC5824808 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Martinez Pierre P Mallo Diego D Paulson Thomas G TG Li Xiaohong X Sanchez Carissa A CA Reid Brian J BJ Graham Trevor A TA Kuhner Mary K MK Maley Carlo C CC
Nature communications 20180223 1
The low risk of progression of Barrett's esophagus (BE) to esophageal adenocarcinoma can lead to over-diagnosis and over-treatment of BE patients. This may be addressed through a better understanding of the dynamics surrounding BE malignant progression. Although genetic diversity has been characterized as a marker of malignant development, it is still unclear how BE arises and develops. Here we uncover the evolutionary dynamics of BE at crypt and biopsy levels in eight individuals, including fou ...[more]