Ontology highlight
ABSTRACT:
SUBMITTER: Pierce BL
PROVIDER: S-EPMC5824840 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature communications 20180223 1
Inherited genetic variation affects local gene expression and DNA methylation in humans. Most expression quantitative trait loci (cis-eQTLs) occur at the same genomic location as a methylation QTL (cis-meQTL), suggesting a common causal variant and shared mechanism. Using DNA and RNA from peripheral blood of Bangladeshi individuals, here we use co-localization methods to identify eQTL-meQTL pairs likely to share a causal variant. We use partial correlation and mediation analyses to identify >400 ...[more]