Ontology highlight
ABSTRACT:
SUBMITTER: Dunican EM
PROVIDER: S-EPMC5824874 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Dunican Eleanor M EM Elicker Brett M BM Gierada David S DS Nagle Scott K SK Schiebler Mark L ML Newell John D JD Raymond Wilfred W WW Lachowicz-Scroggins Marrah E ME Di Maio Selena S Hoffman Eric A EA Castro Mario M Fain Sean B SB Jarjour Nizar N NN Israel Elliot E Levy Bruce D BD Erzurum Serpil C SC Wenzel Sally E SE Meyers Deborah A DA Bleecker Eugene R ER Phillips Brenda R BR Mauger David T DT Gordon Erin D ED Woodruff Prescott G PG Peters Michael C MC Fahy John V JV
The Journal of clinical investigation 20180205 3
<h4>Background</h4>The link between mucus plugs and airflow obstruction has not been established in chronic severe asthma, and the role of eosinophils and their products in mucus plug formation is unknown.<h4>Methods</h4>In clinical studies, we developed and applied a bronchopulmonary segment-based scoring system to quantify mucus plugs on multidetector computed tomography (MDCT) lung scans from 146 subjects with asthma and 22 controls, and analyzed relationships among mucus plug scores, forced ...[more]