Ontology highlight
ABSTRACT:
SUBMITTER: Latty SL
PROVIDER: S-EPMC5825206 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Latty Sarah Louise SL Sakai Jiro J Hopkins Lee L Verstak Brett B Paramo Teresa T Berglund Nils A NA Cammarota Eugenia E Cicuta Pietro P Gay Nicholas J NJ Bond Peter J PJ Klenerman David D Bryant Clare E CE
eLife 20180124
Infection and tissue damage induces assembly of supramolecular organizing centres (SMOCs)), such as the Toll-like receptor (TLR) MyDDosome, to co-ordinate inflammatory signaling. SMOC assembly is thought to drive digital all-or-none responses, yet TLR activation by diverse microbes induces anything from mild to severe inflammation. Using single-molecule imaging of TLR4-MyDDosome signaling in living macrophages, we find that MyDDosomes assemble within minutes of TLR4 stimulation. TLR4/MD2 activat ...[more]