Dataset Information

Pharmacokinetics of Sucralose and Acesulfame-Potassium in Breast Milk Following Ingestion of Diet Soda.

ABSTRACT:

Objective

The aim of this study was to determine sucralose and acesulfame-potassium (ace-K) pharmacokinetics in breast milk following maternal ingestion of a diet soda.

Methods

Thirty-four exclusively breast-feeding women (14 normal-weight, 20 obese) consumed 12 ounces of Diet Rite Cola, sweetened with 68-mg sucralose and 41-mg ace-K, before a standardized breakfast meal. Habitual non-nutritional sweeteners intake was assessed via a diet questionnaire. Breast milk was collected from the same breast before beverage ingestion and hourly for 6 hours.

Results

Owing to one mother having extremely high concentrations, peak sucralose and acesulfame-potassium concentrations following ingestion of diet soda ranged from 4.0 to 7387.9 ng/mL (median peak 8.1 ng/mL) and 299.0 to 4764.2 ng/mL (median peak 945.3 ng/mL), respectively.

Conclusions

Ace-K and sucralose transfer into breast milk following ingestion of a diet soda. Future research should measure concentrations after repeated exposure and determine whether chronic ingestion of sucralose and acesulfame-potassium via the breast milk has clinically relevant health consequences.

SUBMITTER: Rother KI

PROVIDER: S-EPMC5825238 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Publications

Pharmacokinetics of Sucralose and Acesulfame-Potassium in Breast Milk Following Ingestion of Diet Soda.

Rother Kristina I KI Sylvetsky Allison C AC Walter Peter J PJ Garraffo H Martin HM Fields David A DA

Journal of pediatric gastroenterology and nutrition 20180301 3

<h4>Objective</h4>The aim of this study was to determine sucralose and acesulfame-potassium (ace-K) pharmacokinetics in breast milk following maternal ingestion of a diet soda.<h4>Methods</h4>Thirty-four exclusively breast-feeding women (14 normal-weight, 20 obese) consumed 12 ounces of Diet Rite Cola, sweetened with 68-mg sucralose and 41-mg ace-K, before a standardized breakfast meal. Habitual non-nutritional sweeteners intake was assessed via a diet questionnaire. Breast milk was collected fr ...[more]

PMID: 29077645

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Project description:The use of low and no calorie sweeteners (LNCSs) has increased substantially the past several decades. Their high solubility in water, low absorption to soils, and reliable analytical methods facilitate their detection in wastewater and surface waters. Low and no calorie sweeteners are widely used in food and beverage products around the world, have been approved as food additives, and are considered safe for human consumption by the United States Food and Drug Administration (USFDA) and other regulatory authorities. Concerns have been raised, however, regarding their growing presence and potential aquatic toxicity. Recent studies have provided new empirical environmental monitoring, environmental fate, and ecotoxicity on acesulfame potassium (ACE-K). Acesulfame potassium is an important high-production LNCS, widely detected in the environment and generally reported to be environmentally persistent. Acesulfame-potassium was selected for this environmental fate and effects review to determine its comparative risk to aquatic organisms. The biodegradation of ACE-K is predicted to be low, based on available quantitative structure-activity relationship (QSAR) models, and this has been confirmed by several investigations, mostly published prior to 2014. More recently, there appears to be an interesting paradigm shift with several reports of the enhanced ability of wastewater treatment plants to biodegrade ACE-K. Some studies report that ACE-K can be photodegraded into potentially toxic breakdown products, whereas other data indicate that this may not be the case. A robust set of acute and chronic ecotoxicity studies in fish, invertebrates, and freshwater plants provided critical data on ACE-K's aquatic toxicity. Acesulfame-potassium concentrations in wastewater and surface water are generally in the lower parts per billion (ppb) range, whereas concentrations in sludge and groundwater are much lower (parts per trillion [ppt]). This preliminary environmental risk assessment establishes that ACE-K has high margins of safety (MOSs) and presents a negligible risk to the aquatic environment based on a collation of extensive ACE-K environmental monitoring, conservative predicted environmental concentration (PEC) and predicted no-effect concentration (PNEC) estimates, and prudent probabilistic exposure modeling. Integr Environ Assess Manag 2020;16:421-437. © 2020 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC).

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Dataset Information

Pharmacokinetics of Sucralose and Acesulfame-Potassium in Breast Milk Following Ingestion of Diet Soda.

Objective

Methods

Results

Conclusions

Publications

Pharmacokinetics of Sucralose and Acesulfame-Potassium in Breast Milk Following Ingestion of Diet Soda.

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