The Role of Astrocytes in Multiple Sclerosis.
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ABSTRACT:
SUBMITTER: Ponath G
PROVIDER: S-EPMC5826071 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
The Role of Astrocytes in Multiple Sclerosis.
Ponath Gerald G Park Calvin C Pitt David D
Frontiers in immunology 20180219
The role traditionally assigned to astrocytes in the pathogenesis of multiple sclerosis (MS) lesions has been the formation of the glial scar once inflammation has subsided. Astrocytes are now recognized to be early and highly active players during lesion formation and key for providing peripheral immune cells access to the central nervous system. Here, we review the role of astrocytes in the formation and evolution of MS lesions, including the recently described functional polarization of astro ...[more]
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